CDKN2A and melanoma: Transgenic mice with C57BL/6 genetic background (HGF, Nme1/2+/Δ, Ink4a/p16−/− strains) exposed to an erythematous dose of UV radiation, displayed strong melanin pigmentation, with melanoma mainly located on exposed dorsal skin surfaces, such as the back, neck, top of head, and flanks.