WWOX was first reported to be involved in ASD in 2016, through an analysis of the Autism Genetic Resource Exchange (AGRE) database combined with the Simons Simplex Collection (SSC) dataset, which found CNVs in 12 affected children (but only one unaffected) involving the WWOX gene, suggesting it to be a low-penetrance ASD-locus [191]. This evidence concerns the gene WWOX and autism.