The WWOX gene was first discovered in the early 2000s due to its colocalization in the chromosomal common fragile site (CFS) FRA16D associated with cancer [10], which in turn led to thorough investigations of its role in tumor suppression, DNA damage response, metabolism, and cellular homeostasis, among other functions [11,12,13,14,15]. The gene discussed is WWOX; the disease is neoplasm.