WWOX and microcephaly: Microcephaly was not seen in our size evaluation [57]; therefore this observation is very important and worthy of further studies in light of a review describing microcephaly in only about 30% of the patients [82], and a genome-wide association study (GWAS) that found an intronic single nucleotide variant (SNP) in WWOX (rs10514437) to be a possible influencer of infant white matter volume, but only approached genome-wide statistical significance [188].