An increased expression of certain stemness markers such as Oct4, Sox2, and Nanog has been demonstrated in radio- and chemo-resistant HNSCC cells [40,41,42] and, finally, the CSC-like signature CD44 has been reported to be significantly correlated with an incomplete response to radio- and chemotherapy in patients with locally advanced HNSCC [43]. Here, SOX2 is linked to head and neck squamous cell carcinoma.