TSPO and age-related macular degeneration: Although Tspo KO mice demonstrated some AMD pathological features such as cholesterol efflux defect, accumulation of cholesterol in the retina, increased inflammation and microglial activation, the thickness of outer nuclear layer was not different between WT and Tspo KO mice even at the age of 18 months (Figure 1), suggesting no notable photoreceptor cell death in Tspo KO retinas.