RGS2 and preeclampsia: Of the large family of RGS proteins, RGS2 is of particular importance in buffering this GPCR signaling associated with preeclampsia [213,215] and is present in vascular cells, including endothelial cells [216], as well as many other cell types of the placenta, including trophoblasts, immune cells, and fibroblasts [213,217].