Though not specific to preeclampsia, hydrogen sulfide enhances NO function by impeding cGMP degradation [185], activating eNOS via a PI3K/Akt-induced phosphorylation event [185], facilitating mir-455-3p and subsequent eNOS expression [186], and arbitrating the reduction of nitrite to NO through xanthine oxidase [187]. Here, AKT1 is linked to preeclampsia.