AKT1 and preeclampsia: Among the many molecular cascades implicated in preeclampsia, the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) and mitogen-activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) signaling pathways are essential to trophoblast function and have downstream targets implicated in similar cellular processes, including migration and invasion [56,59,65].