Many conditions, such as catecholaminergic polymorphic ventricular tachycardia (CPVT), heart failure (HF), and AF, have been linked to abnormal SR Ca2+ release and increased phosphorylation of the RyR2 [3,5,27,28]. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.