PRKN and Parkinson disease: Yamaguchi et al. [92] recently purposed a semi-automatic high-throughput assay system for quantitative detection of disease-specific phenotypes in iPSCs-derived DA neurons of patients with familial PD having Parkin or PINK1 mutations which exhibit abnormal mitochondrial homeostasis, thus in order to screen potential therapeutic drugs which may restore impaired mitochondrial homeostasis as observed in PINK1/Parkin neurons.