PRKN and Parkinson disease: The mitochondrial receptor Nip3-like protein X (Nix) can be seen as an alternative mediator of mitophagy, thus representing another potential promising target for PINK1/Parkin-related PD treatment when PINK1-Parkin mediated mitophagy is impaired; Koentjoro et al. [143] found that Nix overexpression rescues mitochondrial function in fibroblast lines derived from homozygous mutated PINK1 patients.