In humans, a simple change from the habitually high palmitic acid (SFA) intake into a high oleic acid diet, oleic acid being an omega-9 monounsaturated fatty acid (MUFA), resulted in a lower secretion of IL-1β, IL-18, and TNFα, as well as less NLRP3 mRNAs in skeletal muscle, potentially lowering the prevalence of insulin resistance and type 2 diabetes [102]. The gene discussed is NLRP3; the disease is Insulin resistance.