FRMD6 and Alzheimer disease: Promisingly, since knockdown of Willin/FRMD6 in neuronal cell lines mirrors the effects of hyper-activated Hippo, with increased cytoplasmic TAZ and decreased total YAP levels [73], the effects of decreased Willin/FRMD6 in AD would align with/exacerbate the effects of downstream Hippo activation leading to neuronal death.