APP and Alzheimer disease: Such interaction partners include TP53BP2/ASPP2, which is involved in inflammatory NF-kB signaling and induction of apoptosis through APP-BP1 [150]; FTL, which is involved in iron-binding and has been associated with microglial activation and increased gamma-secretase production in AD [151]; most interestingly, APP, the precursor molecule for Aβ.