Results from AD mouse models demonstrate that Hippo dysregulation in cortical neurons occurs at an early stage of neuronal death in AD as cytoplasmic sequestration of YAP by intracellular Aβ aggregates and increased LATS1 activation occurs prior to the onset of cognitive impairment in 5xFAD and human mutant APP-KI mouse models [94]. Here, APP is linked to Alzheimer disease.