FRMD6 and breast carcinoma: 14-3-3 proteins may mediate Willin/FRMD6 cytoplasmic retention as disruption of this interaction by point mutation of T28 to A in MCF7 breast cancer cells results in Willin/FRMD6 nuclear localization; however, it should be noted that these studies were conducted using a truncated form of Willin/FRMD6 and with an anti-FLAG antibody as a proxy for Willin/FRMD6 staining [36].