Van Loosdregt has reported that the CD4+ T-cell population of RA patients treated with hydroxy chloroquine (HCQ) (an autophagy inhibitor) increased microtubule-associated proteins 1A/1B light chain 3B (LC3-II) levels and the number of autophagosomes compared to cells from healthy donors [147]. The gene discussed is CD4; the disease is rheumatoid arthritis.