TMPRSS11D and rheumatoid arthritis: Here, the histone H3 of FLS in RA patients was highly acetylated in the promoter region of IL-6 gene, and histone acetyltransferase (HAT) inhibitors, such as curcumin, have been shown to reduce the IL-6 secretion, indicating the importance of epigenetic mechanisms in RA pathogenesis [76].