In addition, neutrophil cytosolic factor 1 (NCF1, rs201802880, major/minor alleles: A/G, amino acid substitution: C to T from arginine to histidine) of the NOX2 complex (also known as p47PHOX), which is essential for ROS initiation, has been shown to play an important role in autoimmune diseases. The gene discussed is NCF1; the disease is autoimmune disease.