Relatively high-level expression of miR-155 in CLL has been also associated with expression of adverse prognostic markers, such as the ζ-chain associated protein of 70 kD (ZAP-70), unmutated immunoglobulin heavy chain variable region genes (IGHV), and/or deletions in 17p or 11q [26]. Here, ZAP70 is linked to B-cell chronic lymphocytic leukemia.