However, in 2006, wild-type TDP-43 was identified as the main component of ubiquitin-positive cytoplasmic aggregates of all cases of familial and sporadic ALS, with the notable exception of SOD1 and FUS patients, thus suggesting a more general role of TDP-43 in ALS pathology [80,81]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.