TARDBP and amyotrophic lateral sclerosis: This has been mostly obtained by studying motor neurons, which indeed are the key players in ALS, but the pathological features that typify ALS-linked mutant TDP-43, FUS, and C9orf72 in neuronal cells, seem to be reproduced, at least in part, in astrocytes and microglia cells, suggesting that RNA dysmetabolism might participate to the inflammatory processes that both cell types orchestrate during disease progression (Figure 2 and Figure 3).