Another specific pathological hallmark of C9orf72-ALS neurons is the intracellular accumulation of five poly-dipeptide repeat (DPR) proteins (poly-GA, -GP, -GR, -PR, and -PA), unconventionally produced by repeat-associated non-AUG (RAN) translation from sense and antisense expanded transcripts [126]. Here, C9orf72 is linked to amyotrophic lateral sclerosis.