In addition to neuronal inclusions, glia-specific TDP-43 and FUS aggregates have been detected in ALS patients [25,73,78,79,80], thus suggesting that even both loss and gain-of-function mechanisms in microglia and astrocytes bearing mutant TDP-43 and FUS might be involved in the disease pathogenesis. Here, TARDBP is linked to amyotrophic lateral sclerosis.