It has been found that reactive microglia of C9orf72-ALS patient post-mortem motor cortex and spinal cord is characterized by a strong accumulation of LAMP1-positive lysosomes, differently from sporadic ALS samples [106], thus suggesting potential lysosomal alterations in C9orf72 cases, a pathway already strongly implicated in ALS pathology by genetic and experimental findings [130]. Here, C9orf72 is linked to amyotrophic lateral sclerosis.