Importantly, hnRNP H sequestration has also been observed in post-mortem tissues from C9orf72-ALS patients [115,122,123], and consequent aberrant alternative splicing of multiple known hnRNP H targets has been detected in brains from both C9orf72 and sporadic ALS patients [122,124,125]. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.