Moreover, PGRMC2 is highly expressed in ovarian cancer cells, and in vitro studies showed that its P4-mediated activation resulted in the inhibition of cell migration [177] and apoptosis through PI3K/Phosphatase and Tensin Homolog (PTEN)/Akt/GSK-3β axis [172] (Figure 4). This evidence concerns the gene PTEN and ovarian carcinoma.