AKT1 and testicular germ cell tumor: Conversely, in Leydig cell tumor (a different testicular germ cell tumor subtype compared to seminoma), GPER activation is correlated with decreased proliferation, increased apoptosis [121] and perturbance of lipid metabolism and steroidogenesis via PI3K/Akt/mTOR pathway impairment [123], suggesting that, for testicular germ cell tumors, GPER-mediated effects on cell survival and proliferation depend on specific cell type (Figure 2).