AKT1 and ovarian cancer: Indeed, several studies reported its involvement also in other hormone-sensitive cancers, including testicular Leydig cell tumor proliferation and invasion through Transforming Growth Factor beta (TGF-β) alternative pathway [169], endometrial cancer [170] and ovarian cancer, in which PGRMC1 activation promotes cell viability, growth, proliferation, migration and survival through PI3K/Akt-mediated inhibition of apoptosis [171,172] (Figure 4).