Moreover, GPER appears to be required for stemness maintenance in cancer stem cells via PKA/Bcl-2 associated agonist of cell death (BAD) pathway [96] and the development of chemoresistance via EGFR/ERK/Akt-mediated ATP Binding Cassette, Subfamily G, Member 2 (ABCG2) expression [97]. The gene discussed is MAPK1; the disease is cancer.