Moreover, in addition to environmental chemicals and pollutants, also plant-derived compounds have been shown to exert anti-androgenic and mAR-directed mechanism of endocrine disruption [32], although the roles of ZIP9, OXER1, and GPRC6A in mediating mechanisms of cancer progression activated by phyto-antiandrogens have still to be elucidated. This evidence concerns the gene OXER1 and cancer.