These effects could be particularly relevant in shaping pivotal TME characteristics, since the misregulated and unhealthy Pro-tumor Inflammation (PTI), directly correlated with TNF-α and monocytes/macrophages action, has been shown to facilitate the oncogenic process by promoting tumor growth, survival and metastasis and to suppress the antitumoral immune response, leading to TME alterations [197]. The gene discussed is TNF; the disease is neoplasm.