GPER not only suppresses the proliferation of ovarian cancer cells by blocking tubulin polymerization [108,109], but its activation also led to a transcriptome response associated with growth inhibition in ovarian cancer cells [110] and triggered a ERK1/2-mediated trimethylation of Histone H3 at Lysine 4 (H3K4me3) to repress migration and proliferation in vitro [111]. This evidence concerns the gene GPER1 and ovarian cancer.