In this regard, TRPM8 has been reported to activate Akt and Glycogen Synthase Kinase 3 beta (GSK-3β) pathway to promote EMT and breast cancer aggressiveness [61] and to regulate proliferation, migration, and autophagy by activating AMP-Activated Protein Kinase (AMPK) and Unc-51 Like Autophagy Activating Kinase (ULK1) pathway [62] (Figure 1). The gene discussed is AKT1; the disease is breast carcinoma.