In addition, the activation of PGRMC1 triggered by ethynylestradiol (EE) and other estrogen-like compounds has been shown to induce and enhance breast cancer cell proliferation both in vitro and in xenograft [200,201], in line with the previous observation that PGRMC1 can promote breast cancer cell proliferation through an E2-induced mechanism [202]. This evidence concerns the gene PGRMC1 and breast carcinoma.