AKT1 and breast carcinoma: Indeed, P4-mediated mPRα activation has been found to modulate cell proliferation via PI3K molecular pathway [142]; to decrease apoptosis; to increase mitochondrial potential through Gαi, p42/44 MAPK and Akt signaling cascades [143]; and to upregulate the breast cancer resistance protein (BCRP)—an independent risk factor for breast cancer and possible marker for poor prognosis—through PI3K/Akt/mTOR pathway [144], supporting a role for mPRα in the development and progression of breast cancer through cell death inhibition and its role as a major prognostic marker of poor prognosis (Figure 3).