KLK3 and Familial prostate cancer: Moreover, TRPM8 is highly expressed in the prostate epithelium, its levels rise in primary and hormone naïve prostate cancer metastasis [55], and several clinical data report TRPM8 among other candidate gene markers for metastatic prostate [56,57] and TRPM8 mRNA levels were found significantly upregulated in prostate cancer samples [58] and correlated with those of kallikrein-3 (KLK3, also known as PSA, gamma-seminoprotein or P-30 antigen) [59].