While for ER-X and Gq-mER there are almost no literature data on their possible role in cancer progression [73], and for ERx available data are limited to in vitro observations regarding breast cancer [74], GPER (previously known as G Protein-coupled Receptor 30, GPR30) has been associated to the modulation of signaling pathways involved in tumor growth both in vitro and in vivo [75,76]. This evidence concerns the gene GPER1 and breast carcinoma.