Three HSPA proteins were chosen for this comparison, hsc70, glucose regulated protein 78 (Grp78 encoded by HSPA5) and mortalin (encoded by HSPA9), because they are bound, and their complexes disrupted, by the cancer new investigational agent, Sulfur Heteroarotinoid A2 (SHetA2, NSC 726189) [14]. This evidence concerns the gene HSPA5 and cancer.