While hsc70 was not associated with overall head and neck squamous carcinoma (HNSCC) survival probability (p = 0.23), female patients with high hsc70 expression had significantly worse survival probability compared to females with low hsc70 expression (p < 0.0001), males with high hsc70 expression (p < 0.0001) and males with low/medium hsc70 expression (p = 0.0009), suggesting that hsc70 is prognostic only in females. Here, HSPA8 is linked to head and neck squamous cell carcinoma.