For example, in this study we found that hsc70 overexpression has significant prognostic value in breast cancer, cervical cancer and mesothelioma, and gender-specific association in HNSCC and hepatocellular carcinoma, while low hsc70 expression was significantly associated with worse prognosis in renal cell carcinoma. The gene discussed is HSPA8; the disease is hereditary clear cell renal cell carcinoma.