Subcutaneous administration of hBD-2 to mice with colitis caused by supplementing the water with dextran sodium sulfate (DSS), colitis induced by intracolonic administration of trinitrobenzene sulfonic acid (TNBS), as well as colitis induced by transplantation of CD4+/CD25- T cells to mice with severe combined immunodeficiency (SCID), resulted in a reduction of disease markers, inter alia, by suppression of inflammation in the intestines and reducing weight loss in the animals [68]. Here, CD4 is linked to colitis.