In a mouse model of GDF15 induction as a myomitokine, we could show that endogenous activation of the GDF15–GFRAL pathway leads to increased anxiety related behavior and induces a day-time restricted anorexia by increased hypothalamic corticotropin releasing hormone (CRH) acting via CRH receptor 1 [51]. Here, GDF15 is linked to Anorexia.