As integral parts of the RAS, angiotensin II receptors, including angiotensin II receptor type 1 (AT1R) and angiotensin II receptor type 2 (AT2R) are implicated in tumor angiogenesis and tumor metastasis by modulating vascular wall thickness, vascular injury, and cytokine secretion [9]. The gene discussed is AGTR1; the disease is neoplasm.