SQSTM1 and hepatocellular carcinoma: Nevertheless, by targeting the SQSTM1/p62-mediated degradation of KEAP-1, autophagy induces the stabilization of NFE2L2/NRF2 (nuclear factor (erythroid-derived 2)-like 2) protein and its transcriptional activity, which mainly mediates the antioxidant responses, thus preventing erastin and sorafenib-induced ferroptosis in hepatocellular carcinoma cells [128].