G9a, an H3K9 methyltransferase associated with HDAC1 and YY1, a member of the Krüppel family of transcription factors, forms a silencing multi-molecular complex targeting the repression of the ferroxidase Hephaestin gene, which codes a co-factor of FPN involved in ferric export in breast cancer. Here, EHMT2 is linked to breast carcinoma.