In addition, the inhibition of mitochondrial iron accumulation by the upregulation of the mitochondrial iron exporter CDGSH iron sulfur domain 1 (CISD1, also termed mitoNEET) [126] and the increase in mitochondrial ferritin (FtMt) [127] inhibits ferroptosis suggesting that mitophagy, the selective autophagic degradation of mitochondria, can promote/accelerate ferroptotic cancer cell death. This evidence concerns the gene CISD1 and cancer.