In particular, specific to the KDM5 family H3K4 histone lysine demethylases, KDM5A (named JARID1A/RPB2) was identified to be overexpressed in drug-resistant cells displaying some CSC-like features [83], and the overexpression of the KDM5B (named JARID1B/PLU1) is a marker for identifying a subpopulation of human melanoma CSC-like cells [84]. The gene discussed is KDM5B; the disease is melanoma.