While the amount of LXs might be reduced by inactivation of MAGL, the overall effects of MAGL inactivation are anti-inflammatory and neuroprotective, suggesting that enhanced 2-AG signaling by MAGL inactivation plays a dominant role in the alleviation of TBI-induced neuropathology and synaptic and cognitive deficits [24,40,50]. Here, MGLL is linked to Cognitive impairment.