In humans, CD8+Foxp3+ Tregs are detected in some patients with rheumatoid arthritis (RA) [22], systemic lupus erythematosus (SLE) [23], Epstein-Barr virus (EBV) infections [24], patients with prostate cancer [25] and allogeneic stem cell transplantation [26]. The gene discussed is FOXP3; the disease is systemic lupus erythematosus.