This finding was supported in vitro where CD8+CD28low T cells reduced interferon-gamma (IFN-γ) production from myelin oligodendrocyte glycoprotein (MOG) (MS autoantigen)-specific CD4+ T cells and rendered APCs tolerogenic by downregulating CD40, CD80 and CD86 [53]. The gene discussed is CD8A; the disease is myeloid sarcoma.