In contrast to the result shown in Figure 5B, almost all pRPS6-positive cells co-expressed Nestin (Figure 5C, double-positive cell rate: 73.15 ± 9.41%, Supplementary Table S1), indicating that pRPS6 expression may be associated with malignant progression through the development of GSC in GBM tissues. The gene discussed is NES; the disease is glioblastoma.