Mechanistically, the transcriptional activities of STAT6 downstream of IL-4, and of the peroxisome proliferator-activated receptor Gamma (PPARγ) in conjunction with its co-activator PPARγ-coactivator-1beta (PGC-1β), are key for the differentiation and activation of tumor-associated myeloid cells (Figure 2). Here, PPARG is linked to neoplasm.