TSC2 and sarcoidosis: Consistent with a role of mTORC1 in M2 polarization, the myeloid-specific deletion of the mTORC1 inhibitor Tuberous sclerosis 2 (Tsc2) resulted in the constitutive activation of mTORC1, and led to the expansion of M2 cells in vivo and a sarcoidosis-like granulomatous disease [28].