IDO1 and neoplasm: Su et al. have demonstrated that the induction of the IDO expression in TAMs is triggered by the sensing of phagocytosed tumor DNA by the AIM2 inflammasome, linking antibody-dependent cell phagocytosis (ADCP) in macrophages to the suppression of CD8 T cells and to antibody-dependent cell cytotoxicity (ADCC) in natural killer (NK) cells [49].