CXCL10 and hepatocellular carcinoma: In addition to its involvement in HCC promotion, the gut–liver axis is also implicated in HCC progression, as IL-25 secretion by gut microbiota dysbiosis-induced hyperplastic colonic epithelial tuft cells induces M2-like polarization and CXCL10 expression of hepatic MFs in the tumor microenvironment [360].