TGFB1 and neoplasm: TAMs contribute to tumor growth, angiogenesis, and metastasis through the production of cytokines, including IL-1β, IL-6, IL-10, IL-17, and TNF-α, chemokines, like CCL2, CCL17, CCL22, CXCL10, and CXCL12, growth factors, such as PDGF-β, VEGF, TGF-β, and other factors, including MMPs, SPP1, and cyclooxygenase 2 [11,140,189,361].