Proteins from three infections in the same pathways showed overlapping and direct interaction with each other (Supplementary Figures S10–S12), particularly PSMB7 (proteasome subunit beta type-7) was identified in three pathways from the overlap of HCoV-OC43 and SARS-CoV2 infection proteomes, indicating that the overlapping proteins may be modulated during infection by different strains of HCoV. The gene discussed is PSMB7; the disease is infection.