IFNA1 and COVID-19: Therefore, any perturbation in this response, in terms of a loss of function in responsive genetic loci, regulating Toll-like receptor-3 (TLR3) and IFN-mediated immunity, autoantibodies generation against type I IFN-α2, and IFN-ω, may lead to a life-threatening COVID-19 condition as observed in thousands of patients worldwide [89,90,91].