SIRT1 and diabetic kidney disease: It is also reported that caloric restriction and intermittent fasting prevented DKD via improving NAD-dependent SIRT pathway [237], alleviated kidney inflammation in diabetic mice via activating SIRT1 [238], reduced renal oxidative stress and inflammation via activating SIRT2 [239], and attenuated palmitate-induced ROS production and inflammation in proximal tubular cells via SIRT3-mediated deacetylation [240,241].