The SIRT1 agonists, resveratrol [242,243], and BF175 [172], reduced mitochondrial oxidative stress and apoptosis in podocytes of diabetic mice via regulating SIRT1/PGC-1α and SIRT1/p53 signaling, and the SIRT1/antioxidant response element pathway [244], renal fibrosis, and oxidative stress [245]. Here, SIRT1 is linked to renal fibrosis.