AGT and metastatic neoplasm: Finally, analysis of neuroblastoma cells isolated from the bone marrow of patients with metastatic disease by immunomagnetic enrichment using anti-GD2 monoclonal antibody identified adaptation to the microenvironment by downmodulation of chemokine (C-X3-C motif) ligand 1 (CX3CL1), angiotensinogen (AGT), Na+/K+-ATPase alpha 2 (ATP1A2) and upregulation of several genes commonly expressed by various lineages of bone marrow resident cells, such as S100A8 and A9 (calprotectin), CD177, CD3 and CXCL7.