In cases involving breast cancer patients with bone metastases, the chemotherapeutic armamentarium contains several compounds including anthracyclins (inhibitors of DNA synthesis and RNA synthesis) [223], vinorelbine (microtubule disruptor) [224] and capecitabine (thymidylate synthase inhibitor) [225] combined with surgical resection of the primary and metastatic tumors. This evidence concerns the gene TYMS and metastatic neoplasm.