In the bone microenvironment, both BMP-7 and TGF-β2 have been shown to maintain tumor cell dormancy via reduced focal adhesion kinase (FAK)/EGFR signaling and a high p38 mitogen-activated protein kinase (MAPK) over extracellular signal-regulated kinase (ERK) ratio, favoring cell cycle arrest and inducing a dormant state [89,90]. Here, BMP7 is linked to neoplasm.