In Ewing sarcoma, the pathognomonic driver oncogene EWS-FLI1 modulates several biological pathways including IGF-1, PDGF, VEGF, Wnt and TGF-β signaling, which results in differentiation arrest, proliferation, angiogenesis and immune escape of tumor cells [172]. This evidence concerns the gene EWSR1 and Ewing sarcoma.