It was found that allopregnanolone and its agonists in control cultures of SH-SY5Y cells and amyloid-beta precursor protein (APP)/Aβ-overexpressing cells, which are an in vitro model of Alzheimer’s disease, increase ATP synthesis and intensify mitochondrial respiration under baseline conditions and in the presence of oxidative stress [169]. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.