CD8A and non-small cell lung carcinoma: Nevertheless, the difference in CD8 T cell and Treg infiltration consequently resulted in an increased CD8-to-Treg ratio in the SLIH group in comparison to the SHIH group (median ratio 1.95 and 1.42, respectively, p = 0.005; Figure 5I), a biomarker that was recently found to be predictive of ICI therapy response in non-small cell lung cancer (NSCLC) [49].