Exosomes from healthy adipocytes [256,257,258] rescued the ALS phenotype observed in SOD1-mutated neuronal cells with the following: 1- restitution of the mitochondrial respiratory function [257] and mitochondrial transcription factor (p-CREB and PGC-1α) expression [256]; 2- prevention of oxidative damage in SOD1G93A [256,257,258] SOD1G37R and SOD1A4V [258] neuronal cells; and 3- a significant decrease in SOD1 aggregates two and six days after exosome treatment [256]. Here, SOD1 is linked to amyotrophic lateral sclerosis.