By inference, individuals with reduced CIRS [4], including miRNA maturation and deficits in neurotrophin/Trk, RTK, and Wnt/catenin signaling, neuroprotection (including neurotrophin/Trk and Wnt/catenin signaling, lowered DISC1 expression, and interactions between reduced BDNF, CDH1, CTNNB, and DISC1 may be at an increased risk to develop FEP and FES as a consequence of an immune response following bacterial infections and the ensuing neuro-immune toxicity. The gene discussed is CTNNB1; the disease is bacterial infectious disease.