It would be most interesting to follow over time the clonal expansion of cancer cells carrying the heteroplasmic m.14387A>G/MT-ND6, acquired within the infiltration of II.2 and absent in the rest of the mass, as the weak staining of NDUFS3 only within the infiltration is suggestive of a reduced CI integrity: whether cancer cells keep accumulating or eliminate the heteroplasmic variant to recover a fully functional OXPHOS would likely make the difference between a regression to indolence or malignant progression. The gene discussed is MT-ND6; the disease is cancer.