Altered ion conductivity under low extracellular potassium concentrations (for example Na+ permeability, which shifts homodimeric K2P1.1 (TWIK-1) channels from an inhibitory to an excitatory channel) could link K2P1.1 (TWIK-1) channels to the pathophysiology of hypokalemia-induced rhythm disturbances [137]. The gene discussed is KCNK1; the disease is Hypokalemia.