These antiarrhythmic effects could further be employed for rhythm control in a porcine model of burst pacing induced “persistent” AF, induced via implanted pacemakers using a biofeedback algorithm [53,164] and reproduced with an AAV-mediated anti-K2P3.1 (TASK-1) gene therapy approach [52]. This evidence concerns the gene KCNK3 and atrial fibrillation.