MAPT and Alzheimer disease: Due to the genetic manipulability of mice, several models with altered tau, such as the P301S line PS19, Aβ models including the 5XFAD and APPPS1, or mice expressing both altered tau and Aβ such as the 3xTg mice [63,64,65,66] have been developed to elucidate individual aspects of AD pathology including the formation of NFT or Aβ plaques.