The bioinformatic analysis of bone sarcoma cell line expression data (derived from CCLE) revealed high EPHA2 expression in osteosarcoma, Ewing’s sarcoma and chondrosarcoma; high expression levels were also found in other solid tumors, while low-to-null EPHA2 expression characterized hematological neoplasias. This evidence concerns the gene EPHA2 and bone sarcoma.