VCP and cardiomyopathy: These results indicated that the cardiomyopathy induced by the functional inhibition of VCP is a progressive deterioration process, in which the ventricle enlargement acts as an early alteration and initial myocardial remodeling, and the continued ventricle enlargement further elevates both end-systolic and end-diastolic volumes and increases the cardiac loading, leading to the reduction of the cardiac function at an older age.