PGP and plasma cell myeloma: More recently, the impact of the endocytic pathway regulation in drug resistance mediated by EVs has been also assessed: Rab7A was shown to regulate cisplatin resistance by determining alterations in late endocytic trafficking and subsequent drug efflux through EVs [60]; chemotherapeutic agents were shown to stimulate the secretion and recycling of P-gp-enriched EVs through the dysregulation of endocytic pathway [61] and it was found that manipulation of the endocytic pathway attenuates extracellular vesicle-induced reduction in chemosensitivity to bortezomib in multiple myeloma cells [62].