A number of clinical drugs, e.g., nilotinib (a tyrosine kinase inhibitor with antineoplastic activity), fluoxetine (antidepressant, antiobsessional, anti-anxiety, and immunomodulating agent) and sorafenib (RAF/MEK/ERK inhibitor with anticancer activity) contain trifluoromethylphenyl as an important component responsible for their bioactivity. The gene discussed is MAP2K7; the disease is Anxiety.