Interestingly, our analysis revealed that SNX15, ATP2A1, PDCD10, BET1, and HMGA2 expressions were significantly associated with tumor stages and axillary lymph nodes metastasis of CHOL, and higher expression levels of CHOL-hub genes were significantly associated with higher risks and significantly worse prognoses (HR = 4.61, p = 0.044) of CHOL patients. The gene discussed is BET1; the disease is neoplasm.