ESR1 and breast cancer: Taken together, these observations are consistent with the notion that LATS1 and LATS2 play a pivotal role in RASSF1A-induced cell cycle arrest and senescence and mechanistically explain how the loss of either RASSF1A and/or inactivation of LATS1 and LATS2 contributes to ERα+ breast cancer initiation and progression (Figure 6).