Here, we found that knockdown of LATS1, LATS2 or LATS1+LATS2 almost completely circumvented RASSF1A-mediated suppression of YAP1, ERα and FOXM1 expression (Figure 4A) as well as RASSF1A-induced cell growth and senescence (Figure 5A,B), indicating that LATS kinases are of particular importance for the tumor suppressor function of RASSF1A in ERα-driven breast cancer cells. This evidence concerns the gene ESR1 and breast cancer.