To investigate whether LATS1 and/or LATS2 are indeed responsible for RASSF1A-mediated suppression of YAP1, ERα and FOXM1 expression in ERα+ breast cancer cells, we employed stable knockdown of either LATS1, LATS2 or LATS1+LATS2 in RASSF1A-conditional MCF7 cells. The gene discussed is ESR1; the disease is breast carcinoma.