According to several observations ((1) ANO1’s absence decreases airway secretion, (2) ANO1 is ubiquitously expressed in all the tissue affected by CF, including airway epithelial cells where ANO1 is a secondary chloride channel, (3) ANO1 provides a chloride pathway that is CFTR-independent, and (4) ANO1 is involved in HCO3− secretion, which is highly important for fluid secretion and mucus hydration [76]), increasing ANO1 activity can probably compensate for CFTR deficiency (Figure 3). The gene discussed is ANO1; the disease is cystic fibrosis.