Glucose-related protein 94 (GRP94) is also a member of the HSP90 family uniquely expressed on the ER, but it has a similar function to other HSPs in protein refolding and assembly under stress; therefore, GRP94 overexpression has been observed to play a protumor role in many cancers, including CRC. The gene discussed is HSP90B1; the disease is colorectal carcinoma.