Pluronic® is a mixed copolymer of hydrophobic and hydrophilic polymers that have been shown to inhibit HSP70 expression in CRC cells under hyperthermia; thus, it seems that Pluronic® enhances the toxicity of thermal treatment for CRC cells due to the inhibition of HSP70 activity [91]. The gene discussed is HSPA1A; the disease is colorectal carcinoma.