HSPB1 and cancer: In addition, YangZheng XiaoJi—a Chinese anticancer compound—can also inhibit HSP27 phosphorylation in different cancers, including CRC [98], by inhibiting HSP27 localization with caspase_9; the HSP27 function is inhibited in cancer cells through the inhibition of phosphorylation or its colocalization with caspase-9 [98].