NCOA3 and myocardial infarction: Our findings that AKAP2, PKA and Src3 cooperate to promote the activation of cardioprotective responses are consistent with recent findings showing that a direct activator of steroid receptor co-activators known as MCB-613 reduces cardiac remodeling and preserves heart function after MI by reducing cardiomyocyte apoptosis, infarct size and fibrosis [39].