TFRC and hepatocellular carcinoma: Interestingly, the Jumonji C-domain-containing histone demethylases, an epigenetic regulatory enzyme, is iron-dependent [140], and in hepatocarcinoma (HCC) specimens, a switch expression from TfR2 to TfR1 and overexpression of TfR1 have been associated with tumour dedifferentiation and poor prognosis [141], raising the interesting possibility that dedifferentiation may also be linked to alterations of iron metabolism.