It is noteworthy that other more severe iron overload models affecting hepcidin expression, such as the Hamps and the Hjv knock-out and the hepcidin-resistant model bearing the p.C326S mutation in ferroportin, although presenting pancreatic iron accumulation, do not show liver disease or endocrine problems, probably due to greater resistance to oxidative stress injury of mouse models [117]. The gene discussed is HAMP; the disease is liver disorder.