Moreover, subjects affected by aceruloplasminemia, an autosomal recessive disorder characterised by the lack of ceruloplasmin ferroxidase production with brain and liver accumulation of iron, also show increased risk of diabetes [144] as well as individuals affected by FRDA, the neurodegenerative disorder caused by deficiency of the mitochondrial iron chaperone frataxin [66]. This evidence concerns the gene CP and diabetes mellitus.