While increased recruitment of acetyltransferase including p300/CBP and pCAF to GATA4 and NKX2.5 promoters is associated with increased level of H3K9 acetylation and hypertrophic gene expression, inhibition of p300/pCAF with anacardic acid leads to attenuation of alcohol-induced recruitment of p300/pCAF to hypertrophy responsive gene promoters, decreased H3K9 acetylation, decreased expression of hypertrophy responsive genes and amelioration of cardiac hypertrophy [71,72]. Here, EP300 is linked to cardiac hypertrophy.