Furthermore, p300 inhibitors L002 and C646 reverse AngII-mediated hypertension-induced histone H3K9 acetylation, myofibroblast differentiation in myocardial tissues, left ventricular wall thickness, cardiac hypertrophy and myocardial fibrosis in a murine model [50]. The gene discussed is EP300; the disease is Myocardial fibrosis.