Similar to anacardic acid, low dose of GO-Y030, a synthetic analogue of curcumin and highly effective inhibitor of acetyltransferase p300, blunts TAC-induced increased acetyltransferase p300 activity, H3K9 acetylation, cardiac hypertrophy, myocardial fibrosis, and systolic dysfunction in mice [55]. The gene discussed is EP300; the disease is Myocardial fibrosis.