NPPA and preeclampsia: Using female mice lacking anti-hypertrophic atrial natriuretic peptide (ANP–/–) gene as a genetic model of gestational hypertension, Armstrong and colleagues demonstrated that 10 weeks old ANP+/–(KO) offspring (derived from hypertensive ANP–/– females and ANP+/+ males) develop significant cardiac hypertrophic phenotypes compared to age matched ANP+/–(WT) offspring (derived from normotensive ANP+/+ females and ANP–/– males).