The essential roles of p300 and associated factor pCAF in PE-induced cardiac hypertrophy has been further recognized by the observation that anacardic acid, an alkyl salicylic acid and inhibitor of acetyltransferases, blocks PE-induced cardiac hypertrophy through inhibition of acetylation of histone H3K9 and myocyte enhancer factor-2 (Mef-2) DNA binding activity. This evidence concerns the gene KAT2B and cardiac hypertrophy.