Authors further delineated the underlying mechanism of stage-specific recruitment of p300 to hypertrophy responsive gene promoters and showed that the interaction of acetyltransferase p300 with BRG1, a functional subunit of chromatin remodeling complex, and their recruitments to target genes are increased in late heart failure stage but not in early left ventricular hypertrophy stage [45]. Here, EP300 is linked to heart failure.