As Gallic acid is an inhibitor of acetyltransferases [60,61] including p300, and Gallic acid blunts increased expression of p300 in SHR [59], it is reasonable to interpret that acetyltransferase p300 is one of the key players contributing to cardiac pathologies in this genetic rodent model of hypertension and chronic heart failure. This evidence concerns the gene EP300 and hypertensive disorder.