The significance of OGG1 acetylation and its contribution in controlling atherosclerosis has been further investigated in murine models where control ApoE−/−, OGG1−/−ApoE−/−, SM22α-OGG1 ApoE−/−, and SM22α-OGG1K-R ApoE–/– mice were fed a high-fat diet for 14 weeks. This evidence concerns the gene APOE and atherosclerosis.