ADORA2A and neoplasm: A phase 1/1b study has been published examining in patients with “advanced malignancies” a selective A2AR antagonist, NIR178 (PBF509), an antibody, PDR001, that binds to programmed death-1 (PD-1) protein to restore the anti-tumor activity of effector T lymphocytes and/or a humanized antibody against the 5′-nucleotidase, NZV930 (CTg Identifier: NCT03549000) [73].