Further mechanistic insight revealed that TAM could also influence CSC phenotypes through secretion of several soluble cytokines, including IL-6, TGF-β, and Wnt, further increasing CSC self-renewal and tumor-initiating capacity through activation of downstream NF-κB, STAT3, and Akt signaling molecules (Figure 2) [50]. Here, NFKB1 is linked to neoplasm.