Furthermore, genetic knockout of the NG+/Nestin+ MSC resulted in accelerated metastatic outgrowth, and clinical data analysis based on biopsies from hormone receptor-positive/HER2-negative breast cancers revealed that patients without long-term relapse or bone metastases exhibited a higher frequency detection of TGF-β2 and BMP7 in the bone marrow, suggesting that NG+/Nestin+ MSCs are crucial in the dormancy and proliferation homeostasis maintenance of bone-marrow-residing DTCs [88]. Here, NRGN is linked to breast carcinoma.