NES and breast cancer: Nobre et al. [88] demonstrated one distinct NG+/Nestin+ MSC in the bone marrow and its abundance resulted in intensified secretion of TGF-β2 and BMP7 and activation of common downstream p27, p38, and SMAD through binding with TGFBRIII and BMPRII, respectively, inducing cascade accounting for breast cancer latency in bone marrow.