Notably, we have utilized various anti-inflammatory agents, such as the T cell suppressor abatecept (Orencia) [34], tumor necrosis factor-α inhibitor etanercept [35], B lymphocyte-depleting agent rituximab [36], and IL-17RC [37] to decrease hypertension and circulating factors in RUPP rat model of PE that are also elevated during preeclampsia. This evidence concerns the gene TNF and preeclampsia.