GZMB and neoplasm: Notably, multiple cytotoxic effector-related molecules (i.e., CD107a, granzyme B, perforin, IFN-γ, and 4-1BB) were significantly upregulated in eNKs compared to their expression in PB-NKs (Figure 1c), which suggested that NK cells could show enhanced anti-tumor cytotoxicity following ex vivo expansion.