By ELISA, we thus analysed the serum levels of IL6 and IL8 in a series of non-metastatic OS patients at diagnosis, before treatment (T0) and at the end of the therapeutic protocol (T1), after tumour removal (at 13.94 ± 0.76 months since T0), and found a significant decrease in both IL6 and IL8 at T1 (Figure 1A). This evidence concerns the gene CXCL8 and neoplasm.