Among the 19 mRNAs up-regulated in syndromic fibroblasts, 15 demonstrated analogous modulation in BCC-associated fibroblasts (IL1α, CCL2, CXCL16, IL6, IL18, ICAM, A2M, SFRP2, FGF9, IGF2, IGF1, HGF, HHIP, MTSS1 and GLI2). The gene discussed is IL18; the disease is skin basal cell carcinoma.