Similarly, an array panel for the detection of some mitogenic peptides revealed lessened basic fibroblast growth factor (bFGF) (fold-decrease 0.33 ± 0.30 p = 0.014) and higher insulin growth factor binding protein 6 (IGFBP6; fold-increase 2.1 ± 0.9 p = 0.049) in NBCCS-HFs with respect to normal fibroblasts (Figure 3c,d). This evidence concerns the gene IGFBP6 and Hand-foot syndrome.